✦ LIBER ✦

Antitumor effect of arginine butyrate in conjunction with corynebacterium parvum and interferon

✍ Scribed by Charles Chany; Italina Cerutti

Publisher: John Wiley and Sons
Year: 1982
Tongue: French
Weight: 468 KB
Volume: 30
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910300416

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✦ Synopsis

Abstract

The antitumor effect of arginine butyrate, used alone or in conjunction with interferon (IFN), was studied using randomly selected Swiss mice inoculated i.p. with 10^6^ 180 TG Crocker tumor cells. The results of these different therapeutic regimens were estimated by tumor incidence at 10 days, by the time necessary to protect 50% of the animals, and by the final survival rate. Combined treatment by IFN and arginine butyrate was effective; but in order to compensate for IFN's immune repressive effects, a single injection of Corynebacterium parvum was administered in some experiments prior to IFN and/or arginine butyrate. After this immune potentiation, both IFN and arginine butyrate used separately significantly protected the animals. However, optimal results were obtained when a single C. parvum injection was followed by nine daily alternating shots of arginine butyrate and IFN.

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