𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Antitumor activity of satraplatin in cisplatin-resistant oral squamous cell carcinoma cells

✍ Scribed by Yukio Yamano; Masashi Shiiba; Kenji Negoro; Ken Nakatani; Atsushi Kasamatsu; Masanobu Yamatoji; Kentaro Sakuma; Kenji Ogoshi; Manabu Iyoda; Keiji Shinozuka; Hidetaka Yokoe; Takeshi Wada; Shigeyuki Fujita; Shunichiro Iwasawa; Yuichi Takiguchi; Hideki Tanzawa; Katsuhiro Uzawa

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
529 KB
Volume
33
Category
Article
ISSN
1043-3074

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Background.

The aim of the current study was to identify the antitumor activity of satraplatin in paired cisplatin (CDDP)‐resistant oral squamous cell carcinoma (OSCC) cell line and its parental cell line.

Methods.

CDDP‐resistant (KB‐R) cells and parental cells (KB) pair were used. Viability was assessed using the MTT and clonogenic assay. Real‐time polymerase chain reaction (PCR), glutathione (GSH) assay, and flow cytometric analysis were used for further assessment.

Results.

KB‐R cells did not show cross‐resistance to satraplatin. The expression status of almost all transporters was upregulated in the KB‐R cells. There was no difference in the GSH levels between the KB and KB‐R cells. Flow cytometric analysis indicated that with satraplatin the G2/M phase was arrested in the KB‐R cells. KB‐R cells contain enriched side population cells.

Conclusion.

These data suggested that satraplatin has antitumor activity against the CDDP‐resistant OSCC cells. The mechanism of cross‐resistance to platinum agents seems to be multifactorial. © 2010 Wiley Periodicals, Inc. Head Neck, 2010

📜 SIMILAR VOLUMES

Clinical significance of preoperative sq
Clinical significance of preoperative squamous cell carcinoma antigen in oral-cavity squamous cell carcinoma
✍ Wei-Hung Lin; I-How Chen; Fu-Chan Wei; Jung-Ju Huang; Chung-Jan Kang; Ling-Ling 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 213 KB 👁 1 views

## Abstract ## Objectives/Hypothesis: Previous studies have demonstrated a relationship between elevated serum squamous cell carcinoma (SCC) antigen (SCC‐Ag) levels and shorter survival in cancer patients. Few studies, however, have investigated the role of serum SCC‐Ag levels in oral SCC (OSCC).

Identification of cisplatin-resistance r
Identification of cisplatin-resistance related genes in head and neck squamous cell carcinoma
✍ Yukio Yamano; Katsuhiro Uzawa; Kengo Saito; Dai Nakashima; Atsushi Kasamatsu; Hi 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 French ⚖ 355 KB 👁 2 views

## Abstract Resistance to cisplatin is a major obstacle to successful treatment of head and neck squamous cell carcinoma (HNSCC). To investigate the molecular mechanism of this resistance, we compared the gene expression profiles between the cisplatin‐sensitive SCC cell lines (Sa‐3, H‐1 and KB) and

Immunohistologic study of mononuclear ce
Immunohistologic study of mononuclear cell infiltrates in oral squamous cell carcinomas
✍ Dr. Jyusui Hirota; Eisaku Ueta; Tokio Osaki; Dr. Yasuhiro Ogawa 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 690 KB

## Abstract Intensity of mononuclear cell infiltrates in 50 oral cancer tissues was evaluated by immunohistochemical stainings. The intensity of the infiltrates was graded into four degrees from marked (+ + +) to absent (‐); and the degree of each infiltrated lymphocyte subpopulation including Leu‐

Cell surface antigens in squamous cell c
Cell surface antigens in squamous cell carcinoma of the oral cavity
✍ S. N. Das; Prof. N. N. Khanna; Sushila Khanna; S. Gupta 📂 Article 📅 1986 🏛 John Wiley and Sons 🌐 English ⚖ 1006 KB

The ABH isoantigen was investigated in 80 patients with squamous cell carcinoma of the oral cavity and in their 46 affected lymph nodes. Isoantigen deletion shows a characteristic pattern of benign to malignant transformation of oral cancer. Total loss of isoantigen was found in anaplastic tumours,

Identification and characterization of a
Identification and characterization of autocrine-motility-factor-like activity in oral squamous-cell-carcinoma cells
✍ Akira Ishisaki; Shinichiro Oida; Fumio Momose; Teruo Amagasa; Koichi Rikimaru; H 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 French ⚖ 783 KB

## Abstract A human oral squamous‐cell‐carcinoma cell line, HOC313, was found to produce a factor which stimulates cell motility in an autocrine manner. The motility factor of HOC313 cells also promoted the locomotory activity of B16 murine melanoma cells reported to be sensitive to autocrine motil

Hyperphosphorylation of replication prot
Hyperphosphorylation of replication protein A in cisplatin-resistant and -sensitive head and neck squamous cell carcinoma cell lines
✍ Karoline C. Manthey; Jason G. Glanzer; Diana D. Dimitrova; Greg G. Oakley 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 419 KB 👁 3 views

## Abstract ## Background Resistance to chemotherapy is a major limitation in the treatment of head and neck squamous cell carcinomas (HNSCCs), accounting for high mortality rates in patients. Here, we investigated the role of replication protein A (RPA) in cisplatin and etoposide resistance. ##