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Antitumor activity of erlotinib in combination with capecitabine in human tumor xenograft models

✍ Scribed by Kaori F. -Ouchi; Mieko Yanagisawa; Fumiko Sekiguchi; Yutaka Tanaka

Publisher
Springer
Year
2005
Tongue
English
Weight
409 KB
Volume
57
Category
Article
ISSN
0344-5704

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✍ Ying Chau; Robert F. Padera; Natalie M. Dang; Robert Langer πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 French βš– 532 KB

We have designed a new dextran-peptide-methotrexate conjugate to achieve tumor-targeted delivery of chemotherapeutics. The dextran carrier was selected to allow passive targeting and enhanced permeation and retention (EPR). The peptide linker has also been optimized to allow drug release in the pres