Antitumor activity of DAB389 IL-2 fusion toxin in mycosis fungoides
β Scribed by Mansoor N. Saleh; C.F. LeMaistre; Timothy M. Kuzel; Francine Foss; Leonidas C. Platanias; Gary Schwartz; Mark Ratain; Alain Rook; Cesar O. Freytes; Fiona Craig; James Reuben; Mitchell W. Sams; Jean C. Nichols
- Book ID
- 117396462
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 166 KB
- Volume
- 39
- Category
- Article
- ISSN
- 1097-6787
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Four patients with late stage cutaneous T cell lymphoma (IB-IVA) who had failed at least two previous therapies were treated with DAB 389 IL2 at 9 or 18 Β΅g/kg as 15-min intravenous infusions daily for 5 days every 3 weeks for eight cycles. Mild vascular leak syndrome (VLS) with transient edema, hypo
## Abstract Interleukinβ17 (ILβ17) is a proinflammatory cytokine mainly produced by activated CD4^+^ CD45RO T cells. In mice, we have demonstrated that, depending on the model, ILβ17 may act as a tumor growthβpromoting or βinhibiting factor. In order to address the relevance of these models in huma