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Antitumor Activities of IKP-104, a 4(1H)-Pyrizinone Derivative, on Cultured and Implanted Tumors

✍ Scribed by Mizuhashi, Fukutaro ;Murata, Kyoji ;Kitagaki, Tadaharu ;Nezu, Masao ;Sano, Mituaki ;Tomita, Isao


Book ID
108579175
Publisher
Wiley (Blackwell Publishing)
Year
1990
Tongue
English
Weight
426 KB
Volume
81
Category
Article
ISSN
0910-5050

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✍ Ahmad S. Shawali; Asma M. Mahran; Afaf A. Nada πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 179 KB

## Abstract New functionalized 1,7‐diaryl‐6‐cyano‐1,2,4‐triazolo[4,3‐__a__]pyrimidin‐5(1__H__)‐one derivatives (**5a–j**) were synthesized via reaction of 5‐cyano‐6‐phenyl‐2‐thiouracil **1** with the respective hydrazonoyl halides **2a–j** and their biological activity was evaluated. The mechanism