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Antisense oligonucleotides to human lipocortin-1 inhibit glucocorticoid-induced inhibition of A549 cell growth and eicosanoid release

✍ Scribed by J.D. Croxtall; R.J. Flower

Book ID: 115784070
Publisher: Elsevier Science
Year: 1994
Tongue: English
Weight: 503 KB
Volume: 48
Category: Article
ISSN: 0006-2952
DOI: 10.1016/0006-2952(94)90458-8

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## Lipocortin -I mediates growth inhibition of glucocorticoids in A549 cells by suppressing the release of PGE2 necessary for their proliferation. We now show that 2 peptide fragments derived from the N-terminal portion of lipocortin-I corresponding to amino-acids 13-25 and 21-33 also inhibited A5

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