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Antisense oligonucleotides are effective inhibitors of hepatitis B virus replication in vitro

โœ Scribed by Brent E. Korba; John L. Gerin

Book ID
113259084
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
1007 KB
Volume
28
Category
Article
ISSN
0166-3542

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We have shown that antisense oligonucleotides can be targeted to hepatitis B virus (HBV)-infected cells, resulting in specific inhibition of viral protein synthesis and replication in vitro. The targeting system was based on the internalization of DNA complexes by highly selective receptors for gala