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Antisense inhibition of Bcr-Abl/c-Abl synthesis promotes telomerase activity and upregulates tankyrase in human leukemia cells

✍ Scribed by Rumiana Bakalova; Hideki Ohba; Zhivko Zhelev; Takanori Kubo; Masayuki Fujii; Mitsuru Ishikawa; Yasuo Shinohara; Yoshinobu Baba


Book ID
117106441
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
1003 KB
Volume
564
Category
Article
ISSN
0014-5793

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✍ Fabrizio Manetti; Annalisa Pucci; Matteo Magnani; Giadaβ€…A. Locatelli; Chiara Bru πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 460 KB

## Abstract A series of pyrazolo[3,4‐d]pyrimidines, previously found to be Src inhibitors, was tested for their ability to inhibit proliferation of three Bcr‐Abl‐positive human leukemia cell lines (K‐562, KU‐812, and MEG‐01), on the basis of the experimental evidence that various Src inhibitors are