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Antiradiation compounds XIII: 1-(dithioacetic acid)-pyridinium betaines

✍ Scribed by William O. Foye; Young Ja Cho; Kyung Hee Oh

Publisher: John Wiley and Sons
Year: 1970
Tongue: English
Weight: 349 KB
Volume: 59
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600590126

No coin nor oath required. For personal study only.

✦ Synopsis

A., owing to the variation possible in conformational preference. The carbonyl oxygen distance from the center of the triple bond ranges from 3.1-4.2 A.

An allowed pattern of atoms can thus be drawn for oxotremorine, Fig. . This calculated energy-allowed pattern clearly mirrors the muscarinic pattern, previously proposed, Fig. .

It can be concluded that oxotremorine can assume a muscarinic pharmacophore, within its structure, on the basis of theoretical calculations of its preferred conformations. Although conclusive pharmacological evidence that would brand oxotremorine as a central muscarinic agonist is still lacking, these studies implicate the feasibility of this mechanism.

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