Antiradiation compounds: XXI. Metal lon complexation of bis(methylthio) and methylthio amino derivatives of 1-methylquinolinium-2-dithioacetic acids
✍ Scribed by William O. Foye; Supaporn Patarapanich
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 435 KB
- Volume
- 76
- Category
- Article
- ISSN
- 0022-3549
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✦ Synopsis
With the assumption that the radiation-protective ability (whole body protection of mice) of the bis(methylthi0) and methylthio amino derivatives of the 1 -methylquinolinium-2-dithioacetic acids may be due to complexation of copper or zinc ions in vivo, the ability of these compounds to form stable metal complexes has been observed. Metal ion stability constants have been determined for three of the compounds with AI(III), Cu(ll), Fe(lll), and Zn(ll) ions, and stabilities somewhat larger than those for simple peptides were found. Structures of the Cu(ll) and Fe(lll) complexes are proposed, based on elemental analyses and infrared absorption. The Cu(ll) complexes are 1 :1 ligandmetal structures that precipitated as double salts with CuCI,, and the Fe(lll) complexes are 2:l structures in which the ligands incorporated an additional sulfur atom.
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C, H, N, and S were done by Multi-Chem Laboratories, Lowell, MA 01851, and all found values were within 20.4% of theoretical values. The IR spectra were obtained with a Perkin Elmer 457 spectrometer,