𝔖 Bobbio Scriptorium
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Antipentylenetetrazol activity of diazepam: A site of action

✍ Scribed by A.Y. Chweh; R.A. Ulloque; E.A. Swinyard

Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
430 KB
Volume
9
Category
Article
ISSN
0272-4391

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✦ Synopsis

The site at which pentylenetetrazol (PTZ) and diazepam interact was explored. Neither Ro 15-1788, a benzodiazepine DZ) receptor antagonist, nor 4,5,6,7-tetrahydroisoxagolo (5,4-c) pyridin-3-01, (THIP), a y-aminobutyric acid (GABAA) receptor ligand, alone had any effect on the incidence of PTZ-induced seizures. Ro 15-1788 inhibited the anti-PTZ activity of diazepam but not that of pentobarbital. THlP had no effect on the anti-PTZ activity of diazepam even after toxic doses. Combination studies with diazepam and progabide (GABAA receptor ligand) or diazepam and pentobarbital demonstrate that the anti-PTZ activity of the individual components interact additively. These results imply that GABAindependent BDZ receptors contribute to the anti-PTZ action of BDZs).

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