The action of clobazam and diazepam on computer-assisted tests of muscle activity: Oculomotor effects

✍ Scribed by K. Schaffler; H. Arnold; E. Hörmann

• Publisher: John Wiley and Sons
• Year: 1982
• Tongue: English
• Weight: 339 KB
• Volume: 2
• Category: Article
• ISSN: 0272-4391
• DOI: 10.1002/ddr.430010708

✦ Synopsis

Schaffler, K., H. Arnold, and E. H6rmann: The action of clobazam and diazepam on computer-assisted tests of muscle activity: oculornotor effects. Drug Dev. Res. S1:039-046, 1982.

The effects of clobazam and diazepam on oculomotor activity were measured using on-line monitoring of saccadic eye movements. The study was carried out in ten healthy volunteers, under double-blind conditions. Each volunteer received a single dose of diazepam 10 mg and 20 mg, clobazam 20 mg and 40 mg, and placebo, each separated by a 7-day washout period. A "split" in drug effect between latency (polysynaptic reflex time) and velocity (muscular function) of eye movements was seen for clobazam, but not for diazepam.