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Antinociceptive Properties of Chloromaleinimides and their Sulphonyl Derivatives

✍ Scribed by Maria Elena Walter; Cristiano Mora; Karoline Mundstock; Mércia M. de Souza; Andréia de Oliveira Pinheiro; Rosendo Augusto Yunes; Ricardo J. Nunes

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
88 KB
Volume
337
Category
Article
ISSN
0365-6233

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✦ Synopsis

Abstract

This report describes the synthesis of new cyclic imides obtained from the reaction between aniline and dichloromaleic anhydride with further chlorosulphonation as well as the reaction between different amines and 4‐methoxyphenol for the synthesis of imidobenzenesulphonyl derivatives. These compounds were tested as antinociceptive agents using the writhing test on mice. Some compounds, when intraperitoneally injected, proved to be potent and dose‐related antinociceptives, being several times more active than many known reference drugs.

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✍ E. Charles Angell; David St C. Black; Naresh Kumar 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 242 KB

## Abstract The complete assignments of the ^13^C NMR resonances of 1‐acetyl‐, 1‐benzoyl‐, 1‐benzenesulphonyl‐, 1‐methanesulphonyl‐ and 1‐(2‐nitrobenzenesulphonyl)‐isatins and their ring‐opened glyoxylic derivatives are reported. The ^13^C assignments of acylisatins were derived from isatin as a mo