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Antineoplastic agents. Structure-activity relationship study of bis(substituted aminoalkylamino)anthraquinones

✍ Scribed by Zee-Cheng, Robert K. Y.; Cheng, C. C.

Book ID
121349837
Publisher
American Chemical Society
Year
1978
Tongue
English
Weight
458 KB
Volume
21
Category
Article
ISSN
0022-2623

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Structure-activity relationship study of
Structure-activity relationship study of anthraquinones: 1, 4-dihydroxy-5, 8-bis[[2-(2-hydroxyethoxy)ethyl]amino]-9, 10-anthracenedione, an analog of an established antineoplastic agent
✍ Robert K. Y. Zee-Cheng; C. C. Cheng πŸ“‚ Article πŸ“… 1982 πŸ› John Wiley and Sons 🌐 English βš– 188 KB

An oxygen analog of the antineoplastic anthraquinone, 1,4-dihydroxy-5,8-bis[ [2-(2-hydroxyethyl)amino]ethyl)amino -9,lO -anthracenedione, was synthesized. This compound, 1,4-dihydroxy-5,8bis[ [2-(2-hydroxyethoxy)ethyI]amino] -9,10-anthracenedione, was found to be inactive against P-388 lymphocytic l