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Structural modification study of bis(substituted aminoalkylamino)anthraquinones. An evaluation of the relationship of the [2-[(2-hydroxyethyl)amino]ethyl]amino side chain with antineoplastic activity

โœ Scribed by Zee-Cheng, Robert K. Y.; Podrebarac, Eugene G.; Menon, C. S.; Cheng, C. C.


Book ID
111964306
Publisher
American Chemical Society
Year
1979
Tongue
English
Weight
550 KB
Volume
22
Category
Article
ISSN
0022-2623

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Structure-activity relationship study of
โœ Robert K. Y. Zee-Cheng; C. C. Cheng ๐Ÿ“‚ Article ๐Ÿ“… 1982 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 188 KB

An oxygen analog of the antineoplastic anthraquinone, 1,4-dihydroxy-5,8-bis[ [2-(2-hydroxyethyl)amino]ethyl)amino -9,lO -anthracenedione, was synthesized. This compound, 1,4-dihydroxy-5,8bis[ [2-(2-hydroxyethoxy)ethyI]amino] -9,10-anthracenedione, was found to be inactive against P-388 lymphocytic l