Antimycobacterial activity: A facile three-component [3+2]-cycloaddition for the regioselective synthesis of highly functionalised dispiropyrrolidines
โ Scribed by Ang Chee Wei; Mohamed Ashraf Ali; Yeong Keng Yoon; Rusli Ismail; Tan Soo Choon; Raju Suresh Kumar; Natarajan Arumugam; Abdulrahman I. Almansour; Hasnah Osman
- Book ID
- 116318672
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 500 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0960-894X
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๐ SIMILAR VOLUMES
The [3+2] cycloaddition reaction of azomethine ylides with isomerised Morita-Baylis-Hillman adducts, both dipoles and dipolarophiles are derived from isatin, afforded highly functionalised 3,3 0 -dispiro pyrrolidine-and 3,3 0 -dispiropyrrolizidine bisoxindoles in high yields.
## Abstract The products exhibit activities which are comparable or even better than those of the standard agents ethambutol and ciprofloxacin.