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A facile and efficient synthesis of highly functionalised 3,3′-dispiropyrrolidine- and 3,3′-dispiropyrrolizidine bisoxindoles via [3+2] cycloaddition

✍ Scribed by Ponnusamy Shanmugam; Baby Viswambharan; Kodirajan Selvakumar; Suchithra Madhavan

Book ID: 104095121
Publisher: Elsevier Science
Year: 2008
Tongue: French
Weight: 124 KB
Volume: 49
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2008.02.104

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✦ Synopsis

The [3+2] cycloaddition reaction of azomethine ylides with isomerised Morita-Baylis-Hillman adducts, both dipoles and dipolarophiles are derived from isatin, afforded highly functionalised 3,3 0 -dispiro pyrrolidine-and 3,3 0 -dispiropyrrolizidine bisoxindoles in high yields.

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