✍ Scribed by Wożniak, Dorota ;Lamer-Zarawska, Eliza ;Matkowski, Adam
No coin nor oath required. For personal study only.
The four flavonoids baicalin, baicalein, wogonoside, and wogonin have been isolated from Scutellaria baicalensis (Lamiaceae) root extract as main bioactive components. We evaluated their antimutagenic activity as potential chemopreventive natural substances using the Ames test. Free radical scavenging properties have also been measured with the 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) assay. Both crude extract and isolated flavone glycosides and aglycones have antimutagenic and free radical scavenging properties. The lipophilic flavone baicalein has been confirmed to be the most powerful antimutagen among the compounds tested.
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## Abstract Supercritical fluid was used to extract baicalin from the roots of __Scutellaria baicalensis__ Georgi. An orthogonal array design (OAD), OA~9~(3^4^), was employed as a chemometric method for the optimization of the supercritical fluid extraction of baicalin from the herbal medicine. Fou