Antimalarials. Some 9-substituted amino-6-chloro-2-methoxyacridines
β Scribed by Singh, Tara; Stein, Robert G.; Biel, John H.
- Book ID
- 126790876
- Publisher
- American Chemical Society
- Year
- 1973
- Tongue
- English
- Weight
- 201 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0022-2623
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π SIMILAR VOLUMES
## Abstract The carbon of the Nβethyl group of the sideβchain of atabrine (I) has been labelled with carbonβ14 as part of a metabolic study of this compound. The overall radiochemical yield was 38% based on ethylβ1β^14^C iodide.
Absolute configurations have been assigned to the enantiomers of the antimalarial drug quinacrine dihydrochloride. Condensation of ( -)-(R)-4-amino-l-diethylaminopentane (from L-glutamic acid) with 6,9-dichloro-2-methoxyacridine gave ( -)-(R)-6-chloro-9-(4'diethylamino-1'-methylbutyl) amino-2-methox