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Antimalarial antisense activity of hexitol nucleic acids

✍ Scribed by Maria Vega C. Flores; David Atkins; Thomas Stanley Stewart; Arthur van Aerschot; Piet Herdewijn


Book ID
106131182
Publisher
Springer-Verlag
Year
1999
Tongue
English
Weight
83 KB
Volume
85
Category
Article
ISSN
1432-1955

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To investigate the antisense effect of a pyrrolidine-based oxy-peptide nucleic acid (POPNA), we carried out the LacZ reporter assay using a 12-mer trans-l-POPNA conjugated with a cell-penetrating peptide (antisense reagent). The antisense effect of the conjugated POPNA (inhibition of LacZ activity)