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Antiinflammatory, Gastrosparing, and Antiplatelet Properties of New NO-Donor Esters of Aspirin

✍ Scribed by Cena, Clara; Lolli, Marco L.; Lazzarato, Loretta; Guaita, Elena; Morini, Giuseppina; Coruzzi, Gabriella; McElroy, Stuart P.; Megson, Ian L.; Fruttero, Roberta; Gasco, Alberto

Book ID
121452570
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
147 KB
Volume
46
Category
Article
ISSN
0022-2623

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Nitrososydnone-5-imines and Thiazole-2-nitrosimines are susceptible to photolytic cleavage of the =N-NO bond. This can be achieved with a tungsten lamp. In water the corresponding syndnone imine salts are formed in 90% yield at 37Β°C. Only at higher temp. (7OOC) ring opening is observed. In methanol