Antiinflammatory Effects of an Ethyl Acetate Extract of Euphorbia royleana

✍ Scribed by S. Bani; D. Chand; K. A. Suri; O. P. Suri; O. P. Sharma

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 642 KB
• Volume: 10
• Category: Article
• ISSN: 0951-418X
• DOI: 10.1002/(sici)1099-1573(199606)10:4<285::aid-ptr761>3.0.co;2-p

✦ Synopsis

The antiinflammatory activity of the ethyl acetate extract (EA) from the residue of an 85% alcohol extract of the latex of plant Euphorbia royleana was tested in mice and rats. In acute tests EA displayed marked antiinflammatory activity. Significant antiarthritic activity was observed in subacute and chronic models of formaldehydeinduced arthritis, adjuvant-induced developing and established arthritis. It produced inhibition of the exudate volume and the leucocyte migration in rats and vascular permeability in mice. EA showed a poor inhibitory effect on the granuloma formation by cotton pellet and croton oil. In in uitro studies EA inhibited the spontaneous contractions of the isolated pregnant rat uterus and oxytocin-induced contractions of virgin rat uterus. It had a very low ulcerogenic potential. The oral LDm in both rats and mice was more than 2500 mg/kg.