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Antihypertensive effect of spirapril and felodipine during repeated administration to spontaneously hypertensive rats

✍ Scribed by A. Monopoli; A. Forlani; S. Milani; E. Ongini


Book ID
114075898
Publisher
Elsevier Science
Year
1988
Weight
500 KB
Volume
20
Category
Article
ISSN
0031-6989

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Tissue distribution of antihypertensive
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## Abstract The distribution of an antihypertensive dipeptide, Val‐Tyr (VY), in the tissues of spontaneously hypertensive rats (SHR) was investigated in this study. A single oral administration of VY (10 mg/kg) to 18‐week‐old SHR resulted in a prolonged reduction of systolic blood pressure (SBP) up