Antihypertensive effect of fractionated sublingual administration of nifedipine in moderate essential hypertension
β Scribed by M. Thibonnier; F. Bonnet; P. Corvol
- Publisher
- Springer
- Year
- 1980
- Tongue
- English
- Weight
- 402 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0031-6970
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π SIMILAR VOLUMES
The nifedipine gastrointestinal therapeutic system (GITS) is a recently developed controlled-release formulation for once-a-day dosing. We evaluated the influence of morning versus evening administration of the drug in a randomized double-blind cross-over study including 15 essential hypertensives.
The effect of 6 weeks of nifedipine 30-60 mg/d on platelet aggregation and lipid parameters has been studied. A diminution in ADP-, adrenaline- and collagen-induced aggregation was observed. In the case of adrenaline- and collagen-stimulated aggregation the decrease was statistically significant. It