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Antihypertensive Agents. I. Non-diuretic 2H-1,2,4-Benzothiadiazine 1,1-Dioxides

✍ Scribed by Topliss, John G.; Sherlock, Margaret H.; Reimann, Hans; Konzelman, Leroy M.; Shapiro, Elizabeth P.; Pettersen, Berit W.; Schneider, Helen; Sperber, Nathan


Book ID
126820935
Publisher
American Chemical Society
Year
1963
Tongue
English
Weight
709 KB
Volume
6
Category
Article
ISSN
0022-2623

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Synthesis of pyrido-1,2,4-thiadiazines r
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Oxidation of 3-phenyl-2H-pyrido[2,3-e]-l,2,4-thiadiazine with sodium hypochlorite and, separately, mchloroperoxybenzoic acid afforded a l,l-dioxide and a 5-oxide derivative, respectively. Further examples of such 1,1dioxide derivatives were synthesised by treating 2-amino-5-methylpyridinΒ’ with ortho