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7-Chloro-3-(4-methyl-1-piperazinyl)-4H-1,2,4-benzothiadiazine-1,1-dioxide a new antihypertensive agent

โœ Scribed by M. Shimizu; K. Yoshida; T. Kadokawa; N. Hatano; J. Kuwashima; K. Nakatsuji; I. Nose; M. Kobayashi


Book ID
112656056
Publisher
Springer
Year
1977
Tongue
English
Weight
331 KB
Volume
33
Category
Article
ISSN
1420-682X

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Determination of 7-chloro-3-(4-methyl-1-
โœ Toshikazu Yamaguchi; Mie Miyamoto; Yuzo Utsui; Yutaka Sekine; Masahisa Hashimoto ๐Ÿ“‚ Article ๐Ÿ“… 1978 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 578 KB

A gas chromatographic method has been developed which enables accurate determination of a new antihypertensive agent, DU-717, in plasma. DU-717 is first extracted with ethyl acetate and, after a clean-up procedure, derivatized with peracetic acid followed by diazomethane to form 2-methyl DU-717 N-ox