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Antihypertensive Agents: Derivatives of 2-Imidazoline and 1,4,5,6-Tetrahydropyrimidine 1a

✍ Scribed by FAUST, J. A.; YEE, L. S.; SAHYUN, M.


Book ID
126403067
Publisher
American Chemical Society
Year
1961
Tongue
English
Weight
401 KB
Volume
26
Category
Article
ISSN
0022-3263

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## Abstract A general method is described for the synthesis of 1‐aryl‐2‐alkyl‐1,4,5,6‐tetrahydropyrimidines 1, by cyclization of __N__‐acyl‐__N__′‐aryltrimethylenediamines 2 with trimethylsilyl polyphosphate. Precursors 2 were obtained by aminolysis of the corresponding __N__‐(3‐bromopropyl)amides