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Antigenic variation in alkaline deoxyribonuclease induced by three different strains of Epstein-Barr virus

✍ Scribed by Marshall V. Williams; Andra Boak; Dr. Ronald Glaser

Book ID
102906958
Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
615 KB
Volume
26
Category
Article
ISSN
0146-6615

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✦ Synopsis

To determine whether biological and/or biochemical variants exist between strains of Epstein-Barr virus (EBV), we superinfected Raji cells with the nontransforming lytic strain of EBV (HR-1), and two isolates that both transform B-lymphocytes and superinfect Raji cells, B95-8, and NPC-EBV. The superinfected cells were assayed for EBV specific DNase. A new electrophoretic form of DNase was observed in cells superinfected with B95-8 EBV as compared to the enzymes induced by the HR-1 and NPC-EBV isolates. There were antigenic differences in the DNase induced by the EBV strains. Since antibody to EBV DNase is a marker for nasopharyngeal carcinoma (NPC), these data may have implications for EBV-associated disease.

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