Antigenic variants of Rous sarcoma virus
โ Scribed by Simons, P.J.; Dougherty, R.M.
- Book ID
- 123236777
- Publisher
- Elsevier Science
- Year
- 1961
- Tongue
- English
- Weight
- 122 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0042-6822
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Virus variants from Af mouse tumours induced by syngeneic cultured cells infected with Carr-Zilber strain of Rous sarcoma virus were studied. These variants were highly oncogenic for adult mice and golden hamsters thus differing from the original Carr-Zilber strain. The coat antigens of these viruse
## Cultures of cells from embryos of Af, C3H-Hg and (CBAT6T6 x Af)F, mice rapidly developed oncogenicity for syngeneic animals after exposure to RSV (Carr-Zilber strain). The tumours of mice were virogenic and contained the group-specific antigen of avian sarcoma-leukosis complex. However, when the