Antigenic relationships between attenuated and pathogenic strains of junin virus

✍ Scribed by Nélida A. Candurra; Elsa B. Damonte; Celia E. Coto

• Publisher: John Wiley and Sons
• Year: 1989
• Tongue: English
• Weight: 487 KB
• Volume: 27
• Category: Article
• ISSN: 0146-6615
• DOI: 10.1002/jmv.1890270215

✦ Synopsis

Antigenic relationships between attenuated and pathogenic strains of Junin virus ( J V ) were investigated. Five strains of either human or rodent origin were tested by cross-neutralization assay with hyperimmune antisera, raised in rabbits, against each strain. Polyclonal antisera could be used to distinguish among these J V strains, as the titer values differed significantly with ratios of homologous to heterologous titers, which ranged from 1.3 to 22.3. This demonstrates, independent of their virulence, a heterogeneity among the J V strains tested. The relatedness among J V strains was expressed quantitatively through a dendrogram based on taxonomic distance coefficients. The field strains of J V were grouped into two clusters, according to their geographic origin.