## Abstract __Trypanosoma cruzi__, the causative agent of the Chagas disease, has a complex life cycle alternating between replicative and noninfective forms with nonreplicative and infective forms of the parasite. Metacyclogenesis is a process that takes place in the invertebrate host, comprising
Antigenic polymorphism of Trypanosoma cruzi: clonal analysis of trypomastigote surface antigens
β Scribed by Fernando Plata; Francisco Garcia Pons; Harvey Eisen
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- English
- Weight
- 929 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0014-2980
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Protective, lytic antibodies are believed to be correlated with active Pypanosoma cruzi infection. In patients with chronic infection, antibodies lysing trypomastigote forms recognize chiefly a-galactosyl structures at the parasite surface. The target molecules on cell-derived trypomastigotes that r
Here, we show that antigal antibodies from Chagas' disease patients react with noninfected host cells previously treated with antigens secreted by the trypomastigote forms of Trypanosoma cruzi. With the exception of human and Old World monkey cells, which are GAL-negative, cells of all mammals expre
## Abstract We propose to analyze the relation between the cellular immune response of Chagas' disease patients after in vitro stimulation of peripheral blood mononuclear cells (PBMC) with recombinant antigens cytoplasmatic repetitive antigen (CRA) or flagellar repetitive antigen (FRA) of __T. cruz