Antiepileptic drugs reduce serum uric acid

✍ Scribed by Klaus-Henning Krause; Peter Berlit; Heinrich Schmidt-Gayk; Bernhard Schellenberg

• Publisher: Elsevier Science
• Year: 1987
• Tongue: English
• Weight: 125 KB
• Volume: 1
• Category: Article
• ISSN: 0920-1211
• DOI: 10.1016/0920-1211(87)90007-6

✦ Synopsis

Uric acid examination in 554 epileptic out-patients under long-term anticonvulsant medication revealed significantly lower serum concentrations compared to a group of normal controls. In patients taking enzyme-inducing drugs, uric acid levels were found to be lower than in those under valproate sodium. In addition, uric acid concentrations showed a negative correlation with duration of therapy in epileptic males. At this time, we can only speculate on the mechanism involved in the reduction of uric acid by enzyme-inducing anticonvulsants as well as on the possible implication of this finding in the treatment of hyperuricemia.