Trends in serum uric acid levels

✍ Scribed by Robert J. Glynn; Edward W. Campion; Jeremiah E. Silbert

• Publisher: John Wiley and Sons
• Year: 1983
• Tongue: English
• Weight: 638 KB
• Volume: 26
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/art.1780260115

✦ Synopsis

Uric acid levels of adult male volunteers in a longitudinal study of human aging rose steadily between 1961 and 1W8. In the 1,141 men with 3 serial physical examinations, who developed no diseases and who took no drugs known to affect uric acid levels, levels rose from means below 5.5 mg/dl in 1961-1963 to means above 6.5 mgldl in 1975-1978. The best predictor of a longitudinal increase in uric acid level was a gain in weight, but this, and other significant predictors, explained only a small portion of the increase in this population. Preliminary data available from a fourth examination indicate that the rising trend has leveled Off.

Numerous epidemiologic studies have described correlates of serum urate levels in adult men (1-7). Factors shown to be associated with hyperuricemia include weight, hyperlipidemia, certain diseases such as atherosclerosis, diabetes, renal diseases, and essential hypertension, and some drugs, especially thiazide diuretics. Age, socioeconomk status, and alcohol consumption have been found by some, but