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Antidiuretic effect of [Sar1, Val5, Ala8] angiotensin II inLophius americanus

✍ Scribed by Churchill, Paul ;Malvin, Richard ;Churchill, Monique ;Beasley, Debbie ;Shier, David

Publisher: John Wiley and Sons
Year: 1985
Tongue: English
Weight: 502 KB
Volume: 233
Category: Article
ISSN: 0022-104X
DOI: 10.1002/jez.1402330104

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✦ Synopsis

We have reported previously that angiotensin I1 increases urine flow and Na and K excretion rates in the aglomerular goosefish Lophius americanus. The present experiments were undertaken to determine if antagonism of endogenous angiotensin has the opposite renal effects. Arterial blood pressure, urine flow, and plasma and urine electrolytes were measured during two consecutive clearance periods in two groups of goosefish. The control group (n = 7) received saline intravenously during both periods; the experimental group (n = 8) received saline during the first period and a competitive antagonist of angiotensin I1 (saralasin, or [Sarl, Val5, Alas] angiotension 11) dissolved

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