## Abstract ## Objective Agomelatine (Valdoxanยฎ) is licensed by the European Medicines Agency for the treatment of major depressive episodes in adults. The objective of this review was to consider how the drug should be used in clinical practice in particular starting, stopping and switching to an
Antidepressants in clinical practice: limitations of assessment methods and drug response
โ Scribed by Sidney H Kennedy; Beata S Eisfeld; Jeffrey H Meyer; R Michael Bagby
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 315 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0885-6222
- DOI
- 10.1002/hup.189
No coin nor oath required. For personal study only.
โฆ Synopsis
There is a recognized gap between knowledge derived from 'efficacy' data - based on usually brief randomized controlled trials and findings in natural practice 'effectiveness' studies. In considering the limitations of current antidepressants in clinical practice, we have selected three clinically important issues to examine in a natural practice data base that has been in existence for several years. These relate to: (1) Diagnostic heterogeneity and potential advances using functional brain imaging; (2) Variability of outcome measures during treatment and (3) Time to response and prediction of outcome. Copyright 2001 John Wiley & Sons, Ltd.
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