Antidepressants and overdose toxicity
β Scribed by J. A. Henry
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 218 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0885-6222
No coin nor oath required. For personal study only.
β¦ Synopsis
Antidepressants relieve depression, but many are highly toxic if taken in overdose, causing over 250 deaths in Britain each year. Ninety-seven per cent of these deaths are due to the older tricyclic drugs. Prescribing antidepressant drugs with lower toxicity in overdose could prevent many of these deaths, and is thus the most immediately available form of suicide prevention, KEY WORDS-Antidepressants, overdose.
π SIMILAR VOLUMES
Standard measures of psychomotor speed and central nervous system arousal were used to assess the behavioural toxicity of several antianxiety and antidepressant agents. The results indicate that, for the agents evaluated, there is a wide variation in the eects on cognitive function. As pharmacoecono
Electrocardiographic changes and quantitative plasma drug levels associated with cyclic antidepressant (TCA) overdose have been the subject of many reports in the medical literature. Heart rate, QRS duration, QT interval, and most recently, the terminal 40 ms QRS (T40) axis have been reported to be
Background. Unlike the related drug carboplatin, cisplatin is highly nephrotoxic and must be given with vigorous intravenous hydration at a much lower dose. As the result of an accidental substitution of cisplatin for carboplatin, a 68-year-old woman received a massive overdose of cisplatin without