Toxic overdose of isoniazid, rifampicin and ethambutol
โ Scribed by C. T. Spalding; W. C. Buss
- Publisher
- Springer
- Year
- 1986
- Tongue
- English
- Weight
- 296 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0031-6970
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๐ SIMILAR VOLUMES
In order to determine the hepatotoxicity of rifampicin in children treated for tuberculosis, a survey was performed of 18 children receiving this medicine in combination with isoniazid. Fifteen of the 18 children (83%) showed a rise in ASAT values and 11 (61%) in ALAT values exceeding 39 U/L. Seven
Tuberculosis chemotherapy involves combination of the drugs isoniazid (INH), rifampicin (RMP) and pyrazinamide (PYR) for a 6-month period. The present work investigated the influence of RMP and PYR on the pharmacokinetic parameters of INH when groups of rats were pre-treated for 21 days with INH alo