Antidepressant-like effects of SR 57227A, a 5-HT3receptor agonist, in rodents
✍ Scribed by M. Poncelet; A. Pério; J. Simiand; G. Gout; P. Soubrié; G. Le Fur
- Publisher
- Springer
- Year
- 1995
- Tongue
- English
- Weight
- 595 KB
- Volume
- 102
- Category
- Article
- ISSN
- 1435-1463
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The techniques of intracellular recording and single-electrode voltage-clamp were used to study the effect of serotonin (5-HT) and the selective 5-HT3 receptor agonist SR 57227A on N-methyl-D-aspartic acid (NMDA)-evoked responses in pyramidal cells of the rat medial prefrontal cortex (mPFC) in in vi
Several substituted 2-pyridazinyl benzoxazole derivatives (VII), (VIII) and (IX) are prepared and evaluated for their utility as 5-HT 3 receptor agonists. A detailed structure-activity relationship study is presented. The most promising results are obtained for the derivatives (VIIa), (VIId) and (VI