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Anticonvulsant Effects of Tigabine, a New Antiepileptic Drug: The Profile of Action in the Rat Kindling Model of Epilepsy.

✍ Scribed by Hitoshi Sato; Kiyoshi Morimoto; Yoshitaka Yamamoto; Takemi Watanabe; Hiroshi Suwaki

Book ID
114748192
Publisher
Wiley (Blackwell Publishing)
Year
1996
Tongue
English
Weight
219 KB
Volume
37
Category
Article
ISSN
0013-9580

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✍ O. Giorgi; G. Carboni; V. Frau; M. Orlandi; V. Valentini; A. Feldman; M. G. Cord πŸ“‚ Article πŸ“… 1996 πŸ› Springer-Verlag 🌐 English βš– 661 KB

The present study was designed to examine the ability of felbamate, a novel antiepileptic agent, to antagonize the increase in seizure severity (i.e., chemical kindling) produced by chronic treatment with initially subconvulsant doses of pentylenetetrazol (PTZ). Rats were treated with PTZ (30 mg/kg,