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Anticonvulsant Effect of Primidone in the Gerbil

✍ Scribed by Frey, H.-H.; Löscher, W.; Reiche, R.; Schultz, D.

Book ID
120556487
Publisher
S. Karger AG
Year
1984
Tongue
English
Weight
947 KB
Volume
28
Category
Article
ISSN
0031-7012

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## Abstract The pharmacokinetics and efficacy of the anticonvulsant primidone (PRM) and its active metabolites, phenobarbital (PB) and phenylethylmalonamide (PEMA), were studied after single‐dose administration in mice. The half‐life of PB is twice that of PRM and PEMA. The plasma/brain ratios prov