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Acute and chronic effects of melatonin as an anticonvulsant in male gerbils

✍ Scribed by Thomas H. Champney; William H. Hanneman; Marie E. Legare; Kevin Appel

Book ID
111263919
Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
556 KB
Volume
20
Category
Article
ISSN
0742-3098

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Acute administration (0.4-12 mumol/kg, i.p.) of the NMDA antagonist D(-)CPPene (3-(2-carboxypiperazin-4-yl)propenyl-1-phosphonic acid; molecular weight = 250.2) dose-dependently reduced the incidence of sound-induced clonic seizures in genetically epilepsy-prone (GEP) rats. The ED50 value against cl