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Anticonvulsant and Sodium Channel-Blocking Properties of Novel 10,11-Dihydro-5 H -dibenz[ b , f ]azepine-5-carboxamide Derivatives

✍ Scribed by Benes, Jan; Parada, António; Figueiredo, Anabela A.; Alves, Paula C.; Freitas, Ana P.; Learmonth, David A.; Cunha, Rodrigo A.; Garrett, José; Soares-da-Silva, Patrício


Book ID
121268645
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
84 KB
Volume
42
Category
Article
ISSN
0022-2623

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Synthesis of trans-10,11-Dihydro-10,11-d
✍ Roland Heckendorn 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 German ⚖ 532 KB

The stereoselectivity of the reduction of 5-carbamoyl-l0, I 1-dihydro-1 l-oxo-SH-dibenz[bflazepine-lO-yl acetate (6), prepared in two steps from 10, I l-dihydro-lO-oxo-5H-dibenz[hflazepine-5-carboxamide (4), has been studied. Among the reagents used, diisobutylaluminum hydride (DIBAH) was found to g