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Anticonvulsant activity of the glial-selective GABA uptake inhibitor, THPO

โœ Scribed by J.D. Wood; D.D. Johnson; P. Krogsgaard-Larsen; A. Schousboe

Book ID
118954940
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
274 KB
Volume
22
Category
Article
ISSN
0028-3908

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Deuterium labelling of the GABA agonists
Deuterium labelling of the GABA agonists THIP, piperidine-4-sulphonic acid and the gaba uptake inhibitor THPO
โœ Povl Krogsgaard-Larsen; Jรธrgen Stage Johansen; Erik Falch ๐Ÿ“‚ Article ๐Ÿ“… 1982 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 470 KB

## Abstract The preparations of deuterium labelled THIP ([7, 7โ€^2^H] 4, 5, 6, 7โ€tetrahydroisoxazolo [5, 4โ€__c__]pyridinโ€3โ€ol) (__7__) and THPO ([4, 4, 7โ€^2^H] 4, 5, 6, 7โ€tetrahydroisoxazoโ€lo[4, 5โ€__c__]pyridinโ€3โ€ol) (__14__) are described. [7, 7โ€^2^H]โ€THIP (__7__) was synthesized by triethylamine c