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Amplification by glycine of the anticonvulsant effect of THPO, a GABA uptake inhibitor

✍ Scribed by Seiler, N.; Sarhan, S.; Krogsgaard-Larsen, P.; Hjeds, H.; Schousboe, A.

Book ID: 121892835
Publisher: Elsevier Science
Year: 1985
Tongue: English
Weight: 315 KB
Volume: 16
Category: Article
ISSN: 0306-3623
DOI: 10.1016/0306-3623(85)90013-8

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## Abstract The preparations of deuterium labelled THIP ([7, 7‐^2^H] 4, 5, 6, 7‐tetrahydroisoxazolo [5, 4‐__c__]pyridin‐3‐ol) (__7__) and THPO ([4, 4, 7‐^2^H] 4, 5, 6, 7‐tetrahydroisoxazo‐lo[4, 5‐__c__]pyridin‐3‐ol) (__14__) are described. [7, 7‐^2^H]‐THIP (__7__) was synthesized by triethylamine c