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Anticonvulsant activity and brain levels of diazepam and its metabolites in mice

โœ Scribed by F. Marcucci; E. Mussini; A. Guaitani; R. Fanelli; S. Garattini

Book ID
118320663
Publisher
Elsevier Science
Year
1971
Tongue
English
Weight
196 KB
Volume
16
Category
Article
ISSN
0014-2999

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๐Ÿ“œ SIMILAR VOLUMES

Relationship between cerebral pharmacoki
Relationship between cerebral pharmacokinetics and anxiolytic activity of diazepam and its active metabolites after a single intra-peritoneal administration of diazepam in mice
โœ E. Dailly; M. Hascoรซt; M. C. Colombel; P. Jolliet; M. Bourin ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 88 KB

The relationship between the cerebral pharmacokinetics of diazepam and its active metabolites (desmethyldiazepam, oxazepam) and the anxiolytic effect evaluated by the four-plates test and the light/dark test were investigated after a single intra-peritoneal injection of diazepam (1 mg/kg or 1.5 mg/k