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Anticoccidial activity in 1-[2-(cycloalkyl)- and 2-(cycloalkylmethyl-4-amino-5-pyrimidyl)methyl]pyridinium salts

โœ Scribed by Mizzoni, Renat H.


Book ID
127292479
Publisher
American Chemical Society
Year
1970
Tongue
English
Weight
474 KB
Volume
13
Category
Article
ISSN
0022-2623

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Conversion of 1-methyl-4-phenyl-1,2,3,6-
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## Abstract Monoamine oxidase B metabolizes 1โ€methylโ€4โ€phenylโ€1,2,3,6โ€tetrahydropyridine (MPTP; **1**) first to 1โ€methylโ€4โ€phenylโ€2,3โ€dihydropyridinium salt (MPDP^+^; **5**), and then to 1โ€methylโ€4โ€phenylphridinium salt (MPP^+^; **7**). Chemical synthesis of MPDP^+^ and its 5โ€methyl analog **6** wa