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Anticipation in schizophrenia

โœ Scribed by Angela Heiden; Ulrike Willinger; Joachim Scharfetter; Kurt Meszaros; Siegfried Kasper; Harald N Aschauer


Book ID
119560347
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
103 KB
Volume
35
Category
Article
ISSN
0920-9964

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Recent studies have observed anticipation (earlier age at onset (AAO) or increased disease severity in successive generations) in familial schizophrenia. In other disorders, where the molecular mechanism (repeat expansion) is known, anticipation varies in degree depending on the sex of the transmitt

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Anticipation is a genetic phenomenon wherein age of disease onset decreases and/ or severity increases in successive generations. Anticipation has been demonstrated for several neuropsychiatric disorders with expanding trinucleotide repeats recently identified as the underlying molecular mechanism.

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