Anticipation in schizophrenia
โ Scribed by Angela Heiden; Ulrike Willinger; Joachim Scharfetter; Kurt Meszaros; Siegfried Kasper; Harald N Aschauer
- Book ID
- 119560347
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 103 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0920-9964
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Recent studies have observed anticipation (earlier age at onset (AAO) or increased disease severity in successive generations) in familial schizophrenia. In other disorders, where the molecular mechanism (repeat expansion) is known, anticipation varies in degree depending on the sex of the transmitt
Anticipation is a genetic phenomenon wherein age of disease onset decreases and/ or severity increases in successive generations. Anticipation has been demonstrated for several neuropsychiatric disorders with expanding trinucleotide repeats recently identified as the underlying molecular mechanism.