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Anticipation in Japanese families with schizophrenia

✍ Scribed by A. Imamura; Sumihisa Honda; Yoshibumi Nakane; Yuji Okazaki


Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
92 KB
Volume
43
Category
Article
ISSN
1435-232X

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Paternal transmission and anticipation i
✍ Husted, Janice; Scutt, Laura E.; Bassett, Anne S. πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 35 KB πŸ‘ 2 views

Recent studies have observed anticipation (earlier age at onset (AAO) or increased disease severity in successive generations) in familial schizophrenia. In other disorders, where the molecular mechanism (repeat expansion) is known, anticipation varies in degree depending on the sex of the transmitt

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Anticipation is a genetic phenomenon wherein age of disease onset decreases and/ or severity increases in successive generations. Anticipation has been demonstrated for several neuropsychiatric disorders with expanding trinucleotide repeats recently identified as the underlying molecular mechanism.

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There have been several reports on anticipation and schizophrenia, and the purpose of the present article is to review the literature and present data from an ongoing family study of schizophrenia. The published data find on average a 10-year difference in the age of onset between the parental and o

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A decrease in age of onset of schizophrenia through consecutive family generations (anticipation) has been found in several studies. Anticipation is known to result from expansion of CAG repeats in genes that determine several neurodegenerative disorders. In a previous study we analysed 26 unilineal