✦ LIBER ✦

Anticentromere antibody

✍ Scribed by Gale Anne Mccarty; John R. Rice; Mary L. Bembe; Franc A. Barada Jr.

Publisher: John Wiley and Sons
Year: 1983
Tongue: English
Weight: 671 KB
Volume: 26
Category: Article
ISSN: 0004-3591
DOI: 10.1002/art.1780260101

No coin nor oath required. For personal study only.

✦ Synopsis

The presence of antibody to the chromosomal centromere appears to be associated with a subset of patients with the limited CREST form of scleroderma. To further define the prognostic value of this autoantibody, 27 patients, who were identified as having anticentromere antibody by screening antinuclear antibody tests using HEp-2 cell substrates, were followed clinically and serologically for 2 years. The presence of anticentromere antibody is common in the limited CREST forms of systemic sclerosis, and it is often the only autoantibody specificity present in the sera of patients with the CREST variant. When compared with other patients who exhibit speckled or nucleolar antinuclear antibody patterns, those with anticentromere antibody had significantly less major organ system involvement.

The introduction of tissue culture substrates for the detection of antinuclear antibodies (ANA) has revealed a diversity of specificities in the sera of patients with scleroderma and its variants (1-3). Previ-From the Division of Rheumatic and Genetic Diseases,

📜 SIMILAR VOLUMES

Anticentromere antibody — clinical assoc

Anticentromere antibody — clinical associations

✍ P. Caramaschi; T. Manzo; D. Biasi; A. Carletto; F. Poli; L. M. Bambara 📂 Article 📅 1995 🏛 Springer 🌐 English ⚖ 303 KB

The objective of this study was to determine the clinical features of 44 patients with anticentromere antibody (ACA) positivity. We undertook a retrospective review of 44 ACA-positive patients (1 male and 43 females with a mean +/- SD age of 53.6 +/- 12.2 years). There were 25 patients with limited

Anticentromere antibody and pulmonary hy

Anticentromere antibody and pulmonary hypertension

✍ Robert M. Bernstein; Ronald A. Asherson; Celia M. Oakley; Graham R. V. Hughes 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 English ⚖ 204 KB

Clinical correlation of anticentromere a

Clinical correlation of anticentromere antibodies

✍ M. Zuber; R. Gotzen; I. Filler 📂 Article 📅 1994 🏛 Springer 🌐 English ⚖ 528 KB

Anticentromere-protein-B-DNA complex act

Anticentromere-protein-B-DNA complex activities in anticentromere antibody-positive patients

✍ Y. Muro; Y. Matsumoto; M. Ohashi 📂 Article 📅 1992 🏛 Springer-Verlag 🌐 English ⚖ 354 KB

Centromere protein B (CENP-B), which is an alphoid DNA binding protein, is the target antigen in autoimmune disease patients (often those with scleroderma). In this study, we analysed activities of anti-CENP-B-DNA complex in anticentromere antibody (ACA)-positive patients using DNA immunoprecipitati

Anticentromere antibodies in primary bil

Anticentromere antibodies in primary biliary cirrhosis

✍ Drew Makinen; Marvin Fritzler; Dr Paul Davis; Sheila Sherlock 📂 Article 📅 1983 🏛 John Wiley and Sons 🌐 English ⚖ 371 KB 👁 1 views

A long-term longitudinal study of antice

A long-term longitudinal study of anticentromere antibodies

✍ Helen D. Tramposch; C. Douglas Smith; Jean-Luc Senecal; Dr. Naomi Rothfield 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 English ⚖ 384 KB 👁 1 views

A longitudinal retrospective study of 37 patients previously tested for anticentromere antibodies (ACA) in 1982 was carried out. No ACA were found in stored sera from 22 ACA-negative patients including 1 patient with CREST (calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, tel