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Anticentromere-protein-B-DNA complex activities in anticentromere antibody-positive patients

✍ Scribed by Y. Muro; Y. Matsumoto; M. Ohashi

Publisher
Springer-Verlag
Year
1992
Tongue
English
Weight
354 KB
Volume
284
Category
Article
ISSN
0340-3696

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✦ Synopsis

Centromere protein B (CENP-B), which is an alphoid DNA binding protein, is the target antigen in autoimmune disease patients (often those with scleroderma). In this study, we analysed activities of anti-CENP-B-DNA complex in anticentromere antibody (ACA)-positive patients using DNA immunoprecipitation with purified CENP-B. The activities correlated with ACA titres and were closely associated with Raynaud's phenomenon. Patients with CREST symptoms (calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, telangiectasia) showed higher activities than those with no symptoms. Our results suggest that autoimmune responses to native CENP-B may have an important role in the pathogenesis of scleroderma.

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